Semax is the seven-residue peptide MEHFPGP, also described as ACTH(4–7)-PGP. The name records a four-residue ACTH segment followed by Pro–Gly–Pro; it is different from the native ACTH(4–10) sequence.
Semax sequence and chemical reference
The Semax record and the sequence in the supplied report agree on MEHFPGP. PubChem lists the reference structure under ACTH (4–7), Pro–Gly–Pro-, with the CAS number and molecular values below.PubChem — Semax, CID 9811102 (opens in a new tab)Supplied Semax 10 mg report — lot SEM-41-3J7 (opens in a new tab)
| Field | Reference value |
|---|---|
| Names | Semax; ACTH(4–7)-PGP |
| Sequence | Met–Glu–His–Phe–Pro–Gly–Pro (MEHFPGP) |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.9 g/mol, PubChem reference structure |
ACTH numbering and shorter sequences
| Name | Sequence | Residue count |
|---|---|---|
| Native ACTH(4–7) | MEHF | 4 |
| Native ACTH(4–10) | MEHFRWG | 7 |
| Semax | MEHFPGP | 7 |
| Shorter sequence recorded by Dolotov et al. | HFPGP | 5 |
| Pro–Gly–Pro | PGP | 3 |
Fragment intervals include both endpoints: positions 4–10 contain seven residues. Semax shares MEHF with that interval, then has PGP in place of RWG. The HFPGP and PGP sequences recorded in the fragment paper identify shorter molecules, rather than alternative spellings of Semax.DailyMed — Cortrosyn, description section (opens in a new tab)PubChem — Semax, CID 9811102 (opens in a new tab)Dolotov et al. (2004) (opens in a new tab)
Read the batch identity separately
The supplied Semax report prints MEHFPGP and describes a freeze-dried material. It records an LC-HRMS reference comparison, chromatographic area purity and a separate measured-content result. Check those fields against the named lot; a shorter fragment name is not a substitute for the stated analytical target.Supplied Semax 10 mg report — lot SEM-41-3J7 (opens in a new tab)
The report does not declare a complete salt or hydrate composition. The formula above describes the PubChem molecule, while water and residual TFA are separate measurements in the batch report.PubChem — Semax, CID 9811102 (opens in a new tab)Supplied Semax 10 mg report — lot SEM-41-3J7 (opens in a new tab)
Product and certificate documents
Sources and further detail
- PubChem — Semax, CID 9811102 (opens in a new tab)
Record already cited in the ACTH-fragment dossier; names, sequence, CAS, formula and weight rechecked for this revision.
- DailyMed — Cortrosyn, description section (opens in a new tab)
Existing dossier source used only for the numbered ACTH amino-terminal sequence.
- Dolotov et al. (2004) (opens in a new tab)
Existing fragment dossier: MEHFPGP, HFPGP and PGP identities only.
- Supplied Semax 10 mg report — lot SEM-41-3J7 (opens in a new tab)
Supplied report: identity wording and analytical fields. Results concern the named sample and lot; this is document transcription, not independent authentication.
Identity sources and supplied documents checked for this revision on 3 October 2026. Report transcription is separate from independent authentication. This article has not undergone independent scientific peer review.