What is receptor selectivity?
Interpret preferential activity at one receptor over another, including comparison ratios, untested targets and the limits of database summaries.
Read the article →Research Hub
Explore peptide science, analytical testing and the documentation behind research materials.
500 articles to explore
Affinity and biological response are different measurements
Understand why a binding constant, a response concentration and a maximum response cannot be used interchangeably when reading peptide research.
Read the article →What happens after a receptor is activated?
Follow receptor activation through intracellular signalling, endpoint measurement and changing responsiveness without assuming one pathway explains every outcome.
Read the article →What are autocrine, paracrine and endocrine signals?
Distinguish self-directed, local and circulating cell communication, and use the source and target cells to interpret a signalling claim.
Read the article →What is peptide turnover?
Understand how peptide abundance can remain steady while molecules are produced and removed, and why a turnover result needs a defined molecular pool.
Read the article →Proteases and peptide cleavage
Read enzyme-mediated peptide cleavage, distinguish terminal and internal cuts, and interpret cleavage-site notation without treating a sequence prediction as a measured result.
Read the article →What is a peptide's biological half-life?
Interpret a half-life as a result tied to a measured species, biological setting and kinetic model, rather than a dosing interval or storage expiry.
Read the article →Why delivery to a biological target matters in research
Understand the difference between adding a peptide to an experiment, detecting it near cells and demonstrating access to the target compartment.
Read the article →How the peptide bond shapes a molecule
Understand local peptide-bond planarity, backbone rotations and the difference between a flat amide group and a three-dimensional peptide chain.
Read the article →N-terminus and C-terminus chemistry
Understand why a peptide's two ends have different chemical identities, how terminal modification changes those groups and why chain ends must be distinguished from side chains.
Read the article →L-amino acids, D-amino acids and stereochemistry
Read amino-acid configuration without confusing D/L with sequence order, optical rotation or a general prediction of peptide behaviour.
Read the article →Glycine and conformational flexibility
Understand how glycine's small side chain changes local backbone possibilities, and why a glycine-containing peptide need not be disordered.
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