MOTS-c peptide: sequence, identity and certificate checks

Check the MOTS-c name, documented 16-residue identity and supplied report details, including structural fields that remain undisclosed.

Substantially revised on 3 October 2026 to focus on molecular identity, naming, chemistry, testing and documentation.

MOTS-c is the name used for a 16-residue peptide identified from the mitochondrial 12S rRNA region. The supplied reports describe that peptide length and compare the samples with a qualified reference, but do not print the complete sequence.

What does the MOTS-c name identify?

Lee and colleagues introduced MOTS-c from a short open reading frame in the mitochondrial 12S rRNA region. The expanded name is mitochondrial open reading frame of the 12S rRNA type-c. Figure 1 gives the reference sequence MRWQEMGYIFYPRKLR. This sequence belongs to the published molecular reference; it is not printed in the supplied reports.Lee et al. (2015), PMID 25738459 (opens in a new tab)

Documented identity fields
FieldReference or document detail
NameMOTS-c
Name expansionMitochondrial open reading frame of the 12S rRNA type-c
Length16 amino-acid residues
Published reference sequenceMRWQEMGYIFYPRKLR
Supplied formLyophilised material in the linked reports
Complete sample sequenceNot printed in either supplied report
CAS, molecular formula and molecular weightNot verified for the supplied reference and chemical form in the checked dossier
Lee et al. (2015), PMID 25738459 (opens in a new tab)MOTS-c 10 mg report: MA-MOT-0021 (opens in a new tab)MOTS-c 20 mg report: MA-MOT-0022 (opens in a new tab)

Two report sizes, two sample records

Linked MOTS-c report examples
ReportLabelled sizeReported content
MA-MOT-002110 mg9.98 mg
MA-MOT-002220 mg19.98 mg
MOTS-c 10 mg report: MA-MOT-0021 (opens in a new tab)MOTS-c 20 mg report: MA-MOT-0022 (opens in a new tab)

Both documents report an LC-HRMS comparison with a qualified reference. They are separate sample records with their own lots and results. Select the certificate for the relevant vial size and lot rather than carrying one report’s values into the other size.MOTS-c 10 mg report: MA-MOT-0021 (opens in a new tab)MOTS-c 20 mg report: MA-MOT-0022 (opens in a new tab)

Complete the reference specification

For a full structural comparison, request the reference sequence, terminal groups, any modifications and the chemical form associated with the certificate. The linked reports identify their reference-matching method but do not supply those fields in full.MOTS-c 10 mg report: MA-MOT-0021 (opens in a new tab)MOTS-c 20 mg report: MA-MOT-0022 (opens in a new tab)

Record a database identifier only when its represented structure has been matched to that specification. A catalogue name or residue count is a useful starting point, but neither substitutes for the missing reference details.MOTS-c 10 mg report: MA-MOT-0021 (opens in a new tab)MOTS-c 20 mg report: MA-MOT-0022 (opens in a new tab)

Product and certificate checks

Sources and further detail

  1. MOTS-c 10 mg report: MA-MOT-0021 (opens in a new tab)

    Supplied PDF re-read on 3 October 2026. Identity wording and document-specific results are transcribed; this is not independent authentication.

  2. MOTS-c 20 mg report: MA-MOT-0022 (opens in a new tab)

    Supplied PDF re-read on 3 October 2026. Identity wording and document-specific results are transcribed; this is not independent authentication.

  3. Lee et al. (2015), PMID 25738459 (opens in a new tab)

    Existing primary source used for name, sequence origin and residue count; the reference sequence in Figure 1 was visually rechecked on 3 October 2026.

Revised 3 October 2026 using the existing source dossier and the specified primary identity records. Report values describe the linked samples. Products are for laboratory research use only.

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